B cells and atherosclerosis
نویسندگان
چکیده
منابع مشابه
B cells and humoral immunity in atherosclerosis.
Insights into the important contribution of inflammation and immune functions in the development and progression of atherosclerosis have greatly improved our understanding of this disease. Although the role of T cells has been extensively studied for decades, only recently has the role of B cells gained more attention. Recent studies have identified differential effects of different B-cell subs...
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Volume 3 • Issue 8 • 1000174 Pharmaceut Anal Acta ISSN: 2153-2435 PAA, an open access journal B cells play a crucial role in both humoral and adaptive immune responses and are detectable in murine and human atherosclerotic arteries. Recent findings from mouse models are starting to re-define the complex role(s) of B-cells in the atherosclerosis. We will discuss the involvement of different B-ce...
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RATIONALE B cells contribute to atherosclerosis through subset-specific mechanisms. Whereas some controversy exists about the role of B-2 cells, B-1a cells are atheroprotective because of secretion of atheroprotective IgM antibodies independent of antigen. B-1b cells, a unique subset of B-1 cells that respond specifically to T-cell-independent antigens, have not been studied within the context ...
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Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in the artery wall. In the arterial intima, lipoprotein components that are generated through oxidative, lipolytic, and proteolytic activities lead to the formation of several danger-associated molecular patterns, whi...
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L ymphocytes and plasma cells have long been detected in the plaque and adventitia of atherosclerotic human arteries, 1 yet their role in regulating atherosclerosis has only recently begun to emerge. 2–6 Two important studies published in 2002 provide evidence for an atheroprotective role for B cells. 3,4 More recently, 2 groups broadened our understanding of B cells and atherosclerosis by prov...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2017
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00859.2016